APP-V by design performs checks on application launch to ensure that the latest version of the application is cached on the device. This action does have an overhead and in environments where the deployment of software is managed outside of APP-V (eg. SCCM or scripts) this behaviour can be considered for being disabled.
The behaviour is controlled by the following registry keys. Setting to 0 disables the action.
HKLM\Software\Wow6432node\Microsoft\Softgrid\4.5\client\configuration
AutoLoadTriggers = 0
AutoLoadTarget = 0
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